I am aware that many folks loved Photosuite and I am one of them. I got it to work on Windows 7 after IE11 was released. I now have it running on Windows 10 with one exception. I cannot add text to my photos. This is not a big deal for me because I am more inclinsed to use the Tools in the suite to touch-up photos.
Here is how I did it:
1. Start Windows 10 in Safe Mode
2. insert CD into optical drive and install the program
3. After restarting the computer go to the MGI folder, delete the Reg.dll
4. Go to MGI folder, right click the .exe file, choose Properites/Compatibility and choose Windows XP SP2.
Let me know it works for you. It's great having the program work (for the most part) and maybe one of you can add a fix to the (adding text) to photos.