Having noticed a few questions regarding Creator 2009 with Vista x64 (64 bit) I thought I'd throw in my 2¢ worth. I installed the download version yesterday afternoon and in spite of my worst fears the entire process went flawlessly. Not a single error message during any phase of the 4 part install which included the program itself, ms net 3.5, content pack, and the HD plugin. As for the operation and functionality of the program itself, yesterday I created one or more detailed test projects with each of the primary modules (VideoWave, Music Disc Creator, MyDVD, PhotoSuite, Sound Editor, etc.) and so far (again to my amazement) not a single error, warning, crash, stall, or slowdown in the workflow. Lastly, the overall speed from end-to-end (launching the suite, launching individual modules, applying effects, editing, rendering, burning etc.) has been excellent. A huge improvement versus any version of EMC I've ever used (and I go all the way back to Easy CD Creator Version 3). I'm not crazy enough to believe I'll never encounter an error or crash but at the risk of sounding like a Roxio salesman, you could say I'm very excited about Creator 2009 ;-)
BTW, before ordering online I poked around for a discount code and found ROXIO15 which (when applied at time of purchase) instantly knocks $15 off the price. AFAIK it would work for the boxed version as well.